The drive is not a valid backup location
The cause behind this issue is that Windows does not recognize USB drives as a valid backup location since earlier they weren’t large enough to store system images. The following solutions could be helpful in resolving The drive is not a valid backup location error:
1] Use a third-party tool to create the backup
While Windows doesn’t allow backing up to the USB drive using its own tool, this restriction doesn’t exist with third-party free backup software like Back4Sure. Try them to back up the files to the USB drive.
2] Create a sub-folder in the USB drive and back up the image there
One good way to bypass the USB drive limitation is to save the backup image of the system in a sub-folder instead of the main drive. Here’s the procedure for the same: Right-click on the USB drive and select Format. Select the File System as NTFS and check the box next to Quick Format. Click on Start to initiate the formatting process. Open the USB drive and right-click anywhere inside the main drive window. Select New > Folder. Name the folder to be created “Image (or anything you please).” Right-click on the folder and select Properties. In the Sharing tab, click on Share. Verify that the Permission level on the System owner (your username) should be Owner. Now try to back up your files keeping the Sub-folder as the backup location. Hope this helps!